variant_annotate

shallow

com.seqbench/workbench · Verify this server

One-box variant lookup against MyVariant.info: accepts an rsID, chrom:pos:ref:alt, genomic HGVS ("chr17:g.7676154G>C"), or transcript HGVS c. ("NM_000546.6:c.215C>G" / "TP53:c.215C>G", bridged via the hgvs_convert tool). Returns a ClinVar significance summary, gnomAD exome/genome allele frequencies, and CADD/SIFT/PolyPhen2/REVEL pathogenicity predictor scores — each section explicitly null when that source has no data, never silently omitted. See the result's own "caveats" for real data-freshness limits (frozen gnomAD/CADD snapshots, periodic ClinVar snapshot).

100.0/100

1 trials · measured 8 days ago

variant_annotate scores 100.0/100 on Vouch's measured behaviour index, from 1 real invocation trials against com.seqbench/workbench, measured 25 Aug 2026 under methodology v0.2.0. Every measured component scored 100.

Component breakdown

ComponentWeightValue
Reliability35%not applicable
Schema integrity25%100.0
Failure behaviour15%not applicable
Latency15%not applicable
Concurrency10%not applicable

Tool details

Transport
remote
Credential class
self-provisionable
Input schema
not declared
Output schema
not declared
Side-effect classification
unclassified

Score history

DayScoreTierMethodology
2026-08-25100.0shallowv0.2.0

Probe evidence

ProbeOutcomes
schema_integritypass: 1

Raw request/response logs are not archived yet — the outcome counts above are drawn directly from every recorded trial.

Embed this score

Available for every tool, scored or not — not a verification perk. Always links back to this page.

Vouch score: variant_annotate
[![Vouch score](https://vouch.tools/api/tools/173acb96-fcc3-4415-9944-135036fb87f8/badge.svg)](https://vouch.tools/tools/173acb96-fcc3-4415-9944-135036fb87f8)
variant_annotate — Vouch